Curr. My name is Tina and I'm a data scientist and YouTuber. Enjoy maximum flexibility and forget about cramming against the clock. . Publications 4. h-index 3. K.H. Her main topic is AI, exploring how it works and, most interestingly, how we increasingly interact with it in the world. Using f4-statistics and qpAdm, we confirm that EHG populations in eastern Europe are a mixture of Villabruna/Oberkassel and ANE ancestries (Supplementary Information, section11 and Supplementary Data 2.K). Kristen Bell. Dr. Huang taught General Chemistry, Quantitative Analysis, and Instrumental Methods for eight years at . under exclusive license to Springer Nature Singapore Pte Ltd. 2022 R. Huang et al. A draft sequence of the Neandertal genome. Population genomics of Mesolithic Scandinavia: investigating early postglacial migration routes and high-latitude adaptation. Branch labels show unique drift lengths; black dots refer to individuals with newly generated data and white dots refer topreviously published genomes;the position of each node does not imply the location where the split took place. Ringbauer, H., Novembre, J. Shes the founder of Coding Black Females, a nonprofit with the aim to provide opportunities for Black female developers to develop themselves, meet familiar faces, network, receive support, and build relationships through having regular meetups., Check out the Coding Black Females website. Dual ancestries and ecologies of the Late Glacial Palaeolithic in Britain. Check out Why is Burnout So Common in Tech? This process allowed us to assign an ancestral or derived haplogroup for covered branches, and to make corrections to calls in cases where, for instance, a more derived haplogroup was called because of residual ancient damage (C-to-T or G-to-A mismatches) in terminal read positions at diagnostic SNPs98 (Supplementary Data 1.A). A deft hand at turning dense and complicated topics into informative and entertaining videos, theres a ton to learn from every single video. However, one of my favorites is using supervised learning techniques, such as random forest, SVM, and XGBoost, to discover which features contribute the most to the success of a product. After DNA lysis, a subset of samples was extracted using silica-coated magnetic particles on an automated liquid handling system (Agilent Technologies Bravo NGS Workstation)57. This is in sharp contrast to the genetic history of Iberian hunter-gatherers, where the spread of the Villabruna/Oberkassel ancestry involved multiple local admixture events with groups carrying high proportions of GoyetQ2 ancestry14 (Fig. Data mining is the process of finding patterns in large amounts of data. Greater San Diego Area. Happy International Womens Day! On the basis of the genetic variation of present-day Europeans, this could imply phenotypic differences between post-14ka hunter-gatherer populations across Europe, with individuals in the Oberkassel cluster possibly exhibiting darker skin and lighter eyes, and individuals in the Sidelkino cluster possibly lighter skin and darker eye colour. On the basis of f4-statistics, we find that individuals assigned to the Oberkassel cluster are closer to the Arene Candide 16 genome than any other Epigravettian-associated group from Italy (Supplementary Data 2.F). Jones, E. R. et al. Tina Huang. Philos. 10, 1218 (2019). 9, 442 (2018). Renaud, G., Slon, V., Duggan, A. T. & Kelso, J. Schmutzi: estimation of contamination and endogenous mitochondrial consensus calling for ancient DNA. Previous studies have shown that two main hunter-gatherer ancestries were predominant across most parts of Europe after around 14kathat is, the western hunter-gatherer (WHG) ancestry, related to the Villabruna cluster, and the eastern hunter-gatherer (EHG) ancestry, showing affinity to both the Villabruna and the ancient north Eurasian (ANE) ancestry found in Upper Palaeolithic Siberian individuals4,36. is also supported by the Deutsche Forschungsgemeinschaft (DFG FOR 2237). Genetically, however, the populations from western and southwestern Europe (today's France and Iberia) differed from contemporaneous populations from central and southern Europe (today's Czech Republic and Italy). Evol. & Strimmer, K. APE: analyses of phylogenetics and evolution in R language. Rohland, N., Glocke, I., Aximu-Petri, A. This is perfect for those of us who haven't a clue what to expect from data science - SQL portion - interviews. In this video @Tina Huang and I go through 5 subscriber submitted resumes and review them. Tina is excellent when it comes to getting overall data science career advice. Then we merged the genotypes from different libraries of the same individual, by randomly picking alleles from available genotype calls, using a custom script. 10 and 11). Science 365, eaat7487 (2019). and H.F. produced a subset of the radiocarbon dates. Int. get subscribed to the Brandwatch Bulletin. The neighbour-joining tree was then reconstructed using the neighbour-joining method implemented in Ape 5.3 package104 of R 3.5.1. A user manual including an installation guide is available at https://haproh.readthedocs.io/en/latest/hapROH_with_contamination.html. The LGM could thus have created a corridor south of the Alps for east-to-west human movements that genetically connected hunter-gatherer populations from the Balkans to Iberia, possibly also via dispersals along existing lower-sea-level coasts32. Sikora, M. et al. Great explanations and feels like real interviews that helps me warm up myself before the real interview! 71, 465492 (2015). 5 Summary of ROH segments detected in Eurasian hunter-gatherers. I also have a newsletter called Boop's Keyboard! The idea of data warehousing is to store large amounts of data in a way that makes it easier to extract and analyse. A. Stoessel performed CT scanning and advised on sampling strategy. Metadata information of studied individuals. 2014-2020.4.01.16-0030) and C.L.S. The generation time is set to 29 years and the error bars show the SE of the admixture date estimated from jackknife resampling (n=22 autosomal chromosomes). This suggests a very small recent effective population size, estimated to be in the order of around 70 individuals (Supplementary Table 2), causing the low genetic diversity in Sicilian Epigravettian hunter-gatherers. Look here to get updated on my recent favourite books, animes, filming equipment and more! Res. Radiocarbon 62, 725757 (2020). Science 363, 12301234 (2019). The genetic history of Ice Age Europe. Follow. The ancestry found in individuals associated with the preceding Aurignacian culture from central Europe (GoyetQ116-1ancestry) gave rise to Gravettian-associated individuals from western and southwestern Europe. The emergence of hunter-gatherer pottery in the Urals and West Siberia: new dating and stable isotope evidence. The formation of human populations in South and Central Asia. 7,794 followers. In the MDS plot, the Le Piage II individual falls particularly close to individuals belonging to the Fournol cluster, suggesting a local genetic continuity of this ancestry during the LGM (Supplementary Fig. Previously, she has interned at Goldman Sachs where she used Python and Scala to implement machine learning techniques for automated anomaly detection. The White House and federal agencies in the U.S. declare the Year of Open Science, listing several actions towards open science. & Meyer, M. Extraction of highly degraded DNA from ancient bones, teeth and sediments for high-throughput sequencing. E.A. My main tasks: Modeling and developing the data structures and processes to optimize the loads of information, discovering insights and creating and maintaining reports. 581582, 128163 (2021). 4, 324333 (2020). TV Actresses. Human bones and teeth were sampled in clean room facilities to minimize the inclusion of modern human DNA contamination during this procedure. It is generated automatically, and you can download, view, and share it at any time. In the box plot the centre line is the median, box bounds delineate the interquartile range and whiskers extend to maximum and minimum values, excluding outliers. 13, 24472461 (2018). I Agree, Brandwatch Bulletin #41: 7 Women in Tech You ShouldKnow. 15-star ratings) or unstructured data (such as social media reviews). The newly reported individuals with over 15,000 SNPs on the Human Origins dataset are shown in black-outlined and filled symbols, as illustrated in the legend on the right, while representative ancient genomes are shown in outlined symbols, as illustrated in the legend at the bottom of the PCA. Max Planck Institute for Evolutionary Anthropology. Second, data-driven product development meshes very well with my own philosophy, commonly known as the 80/20 rule, where 80% of the results come from just about 20% of inputs. Dotted lines delimit geographic regions described in the text. The human remains were processed in dedicated laboratories at the Max Planck Institute for the Science of Human History in Jena (Germany), University of Tbingen (Germany), University of Florence (Italy), Leiden University Medical Center (the Netherlands) and University of Tartu (Estonia). EAGER: efficient ancient genome reconstruction. Created by DataSciencePR. We then attempted to model 250 published and newly reported hunter-gatherers dated to 145ka using qpAdm as a mixture of Oberkassel, Sidelkino, GoyetQ2 ancestries, and an ancestry maximized in Anatolian Neolithic farmers (ANF), as a considerable portion of the sequenced hunter-gatherer genomes date after around 8ka, when ANF ancestry started spreading across Europe. ScienceDaily, 1 March 2023. (Robert Rueda; Tina Saldivar; Lynne Shapiro; Shane Templeton; Houghton Mifflin Company Staff) 2022-112-4f84b - Ecologizr. Hi, my name is Tina and I'm a data scientist at a FAANG company. This suggests that genetic links between southern and southwestern European hunter-gatherers around the time of the LGM extended north of the Pyrenees. 1) we used MUSCLE (-maxiters 2)96 to create a multiple genome alignment of previously published sequences and newly reported mtDNA consensus sequences with q20 according to defined thresholds (minimum average coverage >5-fold, contamination estimate <20%, HaploGrep2 haplogroup assignment consistent with manual assignment). What is surprising is that the Code Cup was so popular that Stanford decided to throw open a Data Science Week in which anyone can submit a code challenge to the top 200 submissions. The horizontal dashed line marks the boundary between Late Pleistocene and Holocene. In the video above, she explains the two major components of big data: data warehousing and data science. To determine the Y-chromosome haplogroups of male individuals, we genotyped the Y-chromosome reads using a Y-SNP list (v.15.73) from the International Society of Genetic Genealogy (ISOGG) dataset, ignoring C-to-T and G-to-A transitions on the forward and reverse reads, respectively. The compiled genotype file used for analyses, including re-genotyped published genomes, has been uploaded at the Edmond Data Repository of the Max Planck Society (https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF). Sci. 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Danielle Fishel. As a Graduate and Consultant in the Business Tax Advisory (Financial Services) team, I provided tax advice and tax compliance services to organisations in the banking and capital markets, wealth and . She is concise, pragmatic and to the point in the videos and it is easy to follow her lectures. NEWSLETTER: https://tinahuang.substack.com/ It's about learning, coding, and generally how to get your sh*t together c: I've been a FAANG data scientist f. This finding, in conjunction with the genetic affinity of the Villabruna cluster to ancient and present-day Near Eastern ancestries4,15,16 (Supplementary Information, section8, Supplementary Fig. Libraries were quantified using the IS7 and IS8 primers59 in a quantification assay using a DyNAmo SYBR Green qPCR Kit (Thermo Fisher Scientific) on the LightCycler 480 (Roche). Peltzer, A. et al. As recommended, we analysed individuals with over 400,000 SNPs called on the 1240k panel101 and we called ROH longer than 4cM (Supplementary Data 3.B). 12). Data warehousing is a field where you often have to deal with a lot of raw data. The genomic history of the Iberian Peninsula over the past 8,000 years. Lazaridis, I. et al. University Universit Chouaib Doukkali; . Tina Huang Popularity . The MySQL engine is also known for being extremely slow compared to others. Science 346, 11131118 (2014). Sci. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. Then pseudo-haploid genotypes were called using pileupCaller 1.4.0.2 (https://github.com/stschiff/sequenceTools) under random haploid calling mode. 9). Peresani, M. et al. We love meeting interesting people and making new friends. Furthermore, the findings show that there had been no genetic exchange between contemporaneous hunter-gatherer populations in western and eastern Europe for more than 6,000 years. Floor Coatings. Nucleic Acids Res. Skoglund, P. et al. A dashed line of 50 cM total ROH is drawn in each panel to help comparison between panels with different y-axis scales. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe. PubMed PLoS Genet. The version used for this work is archived at https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF. You'll likely won't meet her on a day to day basis, but she's always lurking in the Discord and following everybody's progress (not . You probably remember me from class or an event, and that's why this profile is so interesting - it traces my journey from student-athlete at the University of California Davis into a successful entrepreneur with multiple ventures under her belt by age 25, Your email address will not be published. Int. The increasing level of admixture between distinct hunter-gatherer populations from around 8ka onwards indicates an intensified mobility of those forager groups. Planning and Learning in Partially Observable Systems via Filter Stability Noah Golowich (MIT); Ankur Moitra (Math & CSAIL, MIT); Dhruv Rohatgi (MIT) New Subset Selection Algorithms for Low Rank Approximation: Offline and Online David P. Woodruff, Taisuke Yasuda (Carnegie Mellon University) Good Quantum LDPC Codes with Linear Time Decoders Irit Dinur (Weizmann); Min-Hsiu Hsieh (Hon Hai Quantum . Most Popular #86731. Dr. Huang received her BS degree in Chemistry from Bethel College and her PhD in Analytical Chemistry from the University of Kansas in 1998. Finally, we estimated the genetic diversity of Epigravettian-associated individuals in the dataset by calculating both pairwise mismatch rates (PMR) on pseudo-haploid genotypes and individual heterozygosity levels on pseudo-diploid genotypes (Supplementary Data 3.A). ContamLD: estimation of ancient nuclear DNA contamination using breakdown of linkage disequilibrium. Consistent with previous findings, none of the analysed groups show the derived allele at SNP rs4988235 on the LCT gene, which is responsible for lactase persistence. As she gains working experience with one of the FAANG companies, Tina continues to share interesting details about her career journey with the audience. Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis.

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